Antidepressant agents. II. Thiophene analogues of amitriptyline and nortriptyline.

Abstract Text

1. The mean quantal content of the frog end-plate potential was examined under conditions that reduced evoked transmitter release to very low values.2. When the calcium concentration of the Ringer is reduced below 10(-4)M a deviation occurs from the fourth power dependence of the mean quantal content (m) on the calcium concentration such that more quanta are released than is expected from the behaviour of m at higher calcium concentrations.3. At 10(-5)M this extra quantal release is more than two orders of magnitude greater than that predicted by the fourth power relationship.4. The calcium dependence of very low values of m was studied in low calcium Ringer in which the calcium was buffered by either citrate or EDTA. It was found that in the fourth power dependence of m on the external calcium concentration changes rather suddenly to an approximately linear dependence.5. The inclusion of small concentrations of cobalt in the Ringer was found to reduce m to very low values even in the presence of millimolar concentrations of calcium.6. The fourth power dependence of m on the external calcium concentration at high values of m was unaffected by the presence of cobalt. At low quantal contents the transition to a linear dependence on external calcium was again seen, but was shifted to calcium concentrations that did not require buffering.7. The fourth power to linear transition is discussed in terms of its relevance to the relationship between m and the m.e.p.p. frequency.

Authors :-, , , ,


Keywords :-


Mesh Headings :-


Chemical List :-



2016-09-01 00:22:27

Click download button below to get the free Antidepressant agents. II. Thiophene analogues of amitriptyline and nortriptyline. link to pdf of abstract on your facebook profile.

Download Server - Asia Download Server - America Download Server - Europe Download Server - Australia
Citation:- Yom-Tov B, Gronowitz B, Ross B, Stjernström B, .Antidepressant agents. II. Thiophene analogues of amitriptyline and nortriptyline. Acta pharmaceutica Suecica 1974-May;11()149-60 DOI:



Details of Journal

Journal Title - Acta pharmaceutica Suecica

ISSN - 0001-6675

Volume - 11

Issue - 2

Publish date - 1974-May

Language - eng

Country - SWEDEN


SHARE PLEASE -
Read More Similar Articles

Antidepressant agents. 3. Aza-analogues of etryptamine.

Carnmalm B, Misiorny B, Ross B, Stjernström B, .Antidepressant agents. 3. Aza-analogues of etryptamine. Acta pharmaceutica Suecica 1974-May;11()196-200 DOI:.......

Read More

Faltus F, .The depot compounds moditen (fluphenazine) and IMAP (fluspirilene) in clinical practice. Activitas nervosa superior 1974-Aug;16()167-8 DOI:.......


The dependence of evoked transmitter release on external calcium ions at very low mean quantal contents.

Crawford AC, .The dependence of evoked transmitter release on external calcium ions at very low mean quantal contents. The Journal of physiology 1974-Jul;240()255-78 DOI:.......

Read More

Ribodeoxyviruses and cancer.

Temin HM, .Ribodeoxyviruses and cancer. JAMA 1974-Nov;230()1043-5 DOI:.......

Read More

The dental school as a resource for dental health education courses.

Van Stewart A, Wolf A, .The dental school as a resource for dental health education courses. The Journal of school health 1974-Nov;44()501-3 DOI:.......

Read More

Accidental poisoning and the nurse.

Milligan H, .Accidental poisoning and the nurse. Nursing times 1974-Sep;70()1510-1 DOI:.......

Read More

The dental management of children with clefts of the lip and palate.

Peat JH, .The dental management of children with clefts of the lip and palate. The New Zealand dental journal 1974-Apr;70()109-17 DOI:.......

Read More

Accidental ingestion of methotrexate.

Pruitt AW, Kinkade AW, Patterson AW, .Accidental ingestion of methotrexate. The Journal of pediatrics 1974-Nov;85()686-8 DOI:.......

Read More

Accidental infection of laboratory-reared Macaca mulatta with Trypanosoma cruzi.

Cicmanec JL, Neva JL, McClure JL, Loeb JL, .Accidental infection of laboratory-reared Macaca mulatta with Trypanosoma cruzi. Laboratory animal science 1974-Oct;24()783-7 DOI:.......

Read More