Antiproliferative effect of flavonoids from the halophyte Vitex rotundifolia on human cancer cells.

Abstract Text

Three flavonoids, luteolin (1), vitexicarpin (2) and artemetin (3), from the salt marsh plant Vitex rotundifolia, were tested for their anti-proliferative activities in AGS, MCF-7 and HT-29 human cancer cell lines and compared with the control using MTT assay. Among them, 2 was most effective with an IC50 of 6.9 and 22.8 microM against AGS and HT-29 cells, respectively. Inaddition, mRNA expression levels of major apoptosis-related genes such as p21, p53, Bcl-2 andBax in AGS cells were evaluated by reverse-transcription polymerase chain reaction (RT-PCR). Compound 2 not only enhanced most remarkably the expression level of tumor suppressor genes p53 and p21, and pro-apoptotic gene Bax at a concentration of 25 microM, but also suppressed the expression level of antiapoptotic gene Bcl-2 to 20% at the same concentration, thus shifting the Bax/Bcl-2 ratio in favor of apoptosis.

Authors :-, , ,


Keywords :-, , ,


Mesh Headings :-


Chemical List :-, ,



2016-09-08 10:24:16

Click download button below to get the free Antiproliferative effect of flavonoids from the halophyte Vitex rotundifolia on human cancer cells. link to pdf of abstract on your facebook profile.

Download Server - Asia Download Server - America Download Server - Europe Download Server - Australia
Citation:- Kim YA, Kim YA, Seo YA, .Antiproliferative effect of flavonoids from the halophyte Vitex rotundifolia on human cancer cells. Natural product communications 2013-Oct;8()1405-8 DOI:



Details of Journal

Journal Title - Natural product communications

ISSN - 1934-578X

Volume - 8

Issue - 10

Publish date - 2013-Oct

Language - eng

Country - United States


SHARE PLEASE -
Read More Similar Articles

Identification of a xanthine oxidase-inhibitory component from Sophora flavescens using NMR-based metabolomics.

Suzuki R, Hasuike R, Hirabayashi R, Fukuda R, Okada R, Shirataki R, .Identification of a xanthine oxidase-inhibitory component from Sophora flavescens using NMR-based metabolomics. Natural product com.......

Read More

Legoalea PB, Mashimbyeb PB, van Rec PB, .Antiinflammatory and antioxidant flavonoids from Helichrysum kraussii and H. odoratissimum flowers. Natural product communications 2013-Oct;8()1403-4 DOI:.......


Monanchomycalin C, a new pentacyclic guanidine alkaloid from the far-eastern marine sponge Monanchora pulchra.

Tabakmakher KM, Denisenko KM, Guzii KM, Dmitrenok KM, Dyshlovoy KM, Lee KM, .Monanchomycalin C, a new pentacyclic guanidine alkaloid from the far-eastern marine sponge Monanchora pulchra. Natural prod.......

Read More

Novel decaturin alkaloids from the marine-derived fungus Penicillium oxalicum.

Wang PL, Lib PL, Xie PL, Wu PL, Hua PL, Li PL, .Novel decaturin alkaloids from the marine-derived fungus Penicillium oxalicum. Natural product communications 2013-Oct;8()1397-8 DOI:.......

Read More

Alkaloids from an endophytic streptomyces sp. YIM66017.

Zhou H, Yang H, Zhang H, Peng H, Zhao H, Xu H, .Alkaloids from an endophytic streptomyces sp. YIM66017. Natural product communications 2013-Oct;8()1393-6 DOI:.......

Read More

Impact of ploidy change on secondary metabolites and photochemical efficiency in Solanum bulbocastanum.

Caruso I, Dal Piaz I, Malafronte I, De Tommasi I, Aversano I, Zottele I, .Impact of ploidy change on secondary metabolites and photochemical efficiency in Solanum bulbocastanum. Natural product commun.......

Read More

Anticholinesterase and antioxidant activities of fucoxanthin purified from the microalga Phaeodactylum tricornutum.

Kawee-ai A, Kuntiya A, Kim A, .Anticholinesterase and antioxidant activities of fucoxanthin purified from the microalga Phaeodactylum tricornutum. Natural product communications 2013-Oct;8()1381-6 DOI.......

Read More

Inhibition of tumor cells multidrug resistance by cucumarioside A2-2, frondoside A and their complexes with cholesterol.

Menchinskaya ES, Aminin ES, Avilov ES, Silchenko ES, Andryjashchenko ES, Kalinin ES, .Inhibition of tumor cells multidrug resistance by cucumarioside A2-2, frondoside A and their complexes with choles.......

Read More

Two new triterpenoids from Gelsemium elegans and Aglaia odorata.

Liu B, Yang B, Xu B, Liao B, Luo B, Na B, .Two new triterpenoids from Gelsemium elegans and Aglaia odorata. Natural product communications 2013-Oct;8()1373-6 DOI:.......

Read More