Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone.

Abstract Text

Mangiferin, a C-glucosylxanthone (1,3,6,7-tetrahydroxyxanthone-C2-beta-D-glucoside) purified from plant sources was shown to have in vivo growth-inhibitory activity against ascitic fibrosarcoma in Swiss mice. Following in vivo or in vitro treatment, it also enhanced tumor cell cytotoxicity of the splenic cells and peritoneal macrophages of normal and tumor-bearing mice. In vitro treatment of the splenic cells of tumor-bearing mice with mangiferin resulted in augmented killing of tumor cells, both resistant and sensitive to natural killer cells. Mangiferin was also found to antagonize in vitro the cytopathic effect of HIV. The drug appears to act as a potent biological response modifier with antitumor and antiviral effect.

Authors :-, , ,


Keywords :-, ,


Mesh Headings :-


Chemical List :-, , , , , , ,



2016-09-03 01:40:49

Click download button below to get the free Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone. link to pdf of abstract on your facebook profile.

Download Server - Asia Download Server - America Download Server - Europe Download Server - Australia
Citation:- Guha S, Ghosal S, Chattopadhyay S, .Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone. Chemotherapy -;42()443-51 DOI:



Details of Journal

Journal Title - Chemotherapy

ISSN - 0009-3157

Volume - 42

Issue - 6

Publish date - -

Language - eng

Country - SWITZERLAND


SHARE PLEASE -
Read More Similar Articles

Combined effects of S-1, a new form of oral tegafur, plus modulators on ovarian cancer in nude rats.

Suzuki M, Sekiguchi M, Sato M, Shirasaka M, .Combined effects of S-1, a new form of oral tegafur, plus modulators on ovarian cancer in nude rats. Chemotherapy -;42()452-8 DOI:.......

Read More

Qadri SM, Cunha SM, Ueno SM, Walters SM, .Anti-Salmonella activity of CP-99,219, a novel azabicyclo-naphthridone fluoroquinolone. Chemotherapy -;42()439-42 DOI:.......


In vitro and in vivo antibacterial activities of TOC-50, a new parenteral cephalosporin, against Enterococcus faecalis.

Nomura S, Hanaki S, Furukawa S, Unemi S, .In vitro and in vivo antibacterial activities of TOC-50, a new parenteral cephalosporin, against Enterococcus faecalis. Chemotherapy -;42()432-8 DOI:.......

Read More

Activities of piperacillin, ceftazidime, cefepime and cefpirome against Pseudomonas aeruginosa strains with intrinsic ticarcillin resistance.

Bert F, Setbon F, Lambert-Zechovsky F, Branger F, .Activities of piperacillin, ceftazidime, cefepime and cefpirome against Pseudomonas aeruginosa strains with intrinsic ticarcillin resistance. Chemoth.......

Read More

In vitro activity of BAY 12-8039, a new 8-methoxyquinolone.

Dalhoff A, Petersen A, Endermann A, .In vitro activity of BAY 12-8039, a new 8-methoxyquinolone. Chemotherapy -;42()410-25 DOI:.......

Read More

A linear model for the pharmacokinetics of azithromycin in healthy volunteers.

Ripa S, Ferrante S, Prenna S, .A linear model for the pharmacokinetics of azithromycin in healthy volunteers. Chemotherapy -;42()402-9 DOI:.......

Read More

Cotrifazid--an agent against malaria.

Freerksen E, Kanthunkumva E, Kholowa E, .Cotrifazid--an agent against malaria. Chemotherapy -;42()391-401 DOI:.......

Read More

Storage of information in transient auditory memory.

Nousak JM, Deacon JM, Ritter JM, Vaughan JM, .Storage of information in transient auditory memory. Brain research. Cognitive brain research 1996-Nov;4()305-17 DOI:.......

Read More

Event-related potentials and the recollection of associative information.

Rugg MD, Schloerscheidt MD, Doyle MD, Cox MD, Patching MD, .Event-related potentials and the recollection of associative information. Brain research. Cognitive brain research 1996-Nov;4()297-304 DOI:.......

Read More