Aspartic aminopherase activity in liver diseases].

Abstract Text

Oral administration of L-tryptophan to rats produced two main biochemical and pharmacological effects: a marked increase in urinary 5-hydroxyindoleacetic acid excretion, and a significant reduction in the urine flow after a water load. Urinary 5-hydroxyindoleacetic acid excretion reached its maximum 2 to 6 hr after the administration of tryptophan, and it increased with the dose of the amino acid. Antidiuresis was seen after the administration of L-tryptophan, 200 mg/kg, or more. The effect appeared promptly and it was roughly proportional to the dose of the amino acid administered. Both antidiuretic effect and increase in urinary 5-hydroxyindoleacetic acid excretion were more intense after oral than after parenteral administration of L-tryptophan. D-Tryptophan, in oral doses up to 1,000 mg/kg, produced neither an increase in urinary 5-hydroxyindoleacetic acid nor a reduction of diuresis. Available evidence suggests that reduction of urine flow is a consequence of biosynthesis and release of 5-hydroxytryptamine by the gastrointestinal mucosa. Tryptamine produced by direct decarboxylation of L-tryptophan does not seem to play any important role.

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2016-08-31 13:49:07

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Citation:- BEZKOROVAINAIA ZG, .Aspartic aminopherase activity in liver diseases]. Trudy Leningradskogo sanitarno-gigienicheskogo meditsinskogo instituta 1961-;69()73-80 DOI:



Details of Journal

Journal Title - Trudy Leningradskogo sanitarno-gigienicheskogo meditsinskogo instituta

ISSN - 0371-9367

Volume - 69

Issue - 0

Publish date - 1961-

Language - rus

Country - Not Available


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