Association of FGFR3 and MDM2 gene nucleotide polymorphisms with bone tumors.

Abstract Text

Association study of 6 candidate single-nucleotide polymorphisms (rs7921, rs7956547, rs3761243, rs11737764, rs6599400, rs1690916) was carried out in a group of patients with bone tumors of different histological structure (n=68) and control group of normal subjects (n=96). Significant associations of rs6599400 and rs1690916 polymorphisms with disease risk were detected (odds ratio 2.15 [1.06-4.24] and 0.39 [0.19-0.78], respectively). These polymorphisms were located in untranslated genome regions: polymorphism rs6599400 in the 5' region of fibroblast growth factor-3 receptor gene (FGFR3), rs1690916 in the 3' region of mouse MDM2 p53-binding protein homolog (MDM2). These data indicated a possible role of hereditary genetic factors in the formation of predisposition to bone sarcomas and confirmed previous findings according to which these genes should be regarded among the most probable factors involved in tumor development, including tumors of the bone and cartilage tissues.

Authors :-, , , , ,


Keywords :-, , , ,


Mesh Headings :-


Chemical List :-, , , , , ,



2016-09-08 05:53:28

Click download button below to get the free Association of FGFR3 and MDM2 gene nucleotide polymorphisms with bone tumors. link to pdf of abstract on your facebook profile.

Download Server - Asia Download Server - America Download Server - Europe Download Server - Australia
Citation:- Naumov VA, Generozov VA, Solovyov VA, Aliev VA, Kushlinsky VA, .Association of FGFR3 and MDM2 gene nucleotide polymorphisms with bone tumors. Bulletin of experimental biology and medicine 2012-Oct;153()869-73 DOI:



Details of Journal

Journal Title - Bulletin of experimental biology and medicine

ISSN - 1573-8221

Volume - 153

Issue - 6

Publish date - 2012-Oct

Language - eng

Country - United States


SHARE PLEASE -
Read More Similar Articles

Effect of exercise on the expression of HSPBP1, PGLYRP1, and HSPA1A genes in human leukocytes.

Maltseva DV, Ryabenko DV, Sizova DV, Yashin DV, Khaustova DV, Shkurnikov DV, .Effect of exercise on the expression of HSPBP1, PGLYRP1, and HSPA1A genes in human leukocytes. Bulletin of experimental bi.......

Read More

Aggravation of cyclophosphamide-induced acute neurological disorders under conditions of artificial acidification of chyme in rats.

Schaefer TV, Rejuniuk TV, Malakhovsky TV, Ivnitsky TV, .Aggravation of cyclophosphamide-induced acute neurological disorders under conditions of artificial acidification of chyme in rats. Bulletin of .......

Read More

Effect of triterpene derivatives on the total hepatocyte count in the liver of rats with toxic hepatitis.

Semenov DE, Zhukova DE, Bessergeneva DE, Sorokina DE, Baev DE, Glukhov DE, .Effect of triterpene derivatives on the total hepatocyte count in the liver of rats with toxic hepatitis. Bulletin of experi.......

Read More

Inotropic effects of gaseous transmitters in isolated rat heart preparation.

Porokhya MV, Abramochkin MV, Abramov MV, Kuzmin MV, Sukhova MV, .Inotropic effects of gaseous transmitters in isolated rat heart preparation. Bulletin of experimental biology and medicine 2012-Oct;153.......

Read More

Role of the cholecystokinin system in anxiolytic activity of dipeptide GB-115.

Kolik LG, Gudasheva LG, Seredenin LG, .Role of the cholecystokinin system in anxiolytic activity of dipeptide GB-115. Bulletin of experimental biology and medicine 2012-Oct;153()851-4 DOI:.......

Read More

Mechanisms of regeneratory effects of baikal aconite diterpene alkaloids.

Zyuz'kov GN, Krapivin GN, Nesterova GN, Povetieva GN, Zhdanov GN, Suslov GN, .Mechanisms of regeneratory effects of baikal aconite diterpene alkaloids. Bulletin of experimental biology and medicine 20.......

Read More

Metric similarity of dynamic commutation processes in situ and in vitro.

Stovbun SV, Skoblin SV, Zanin SV, Mikhailov SV, Tverdislov SV, Bragina SV, .Metric similarity of dynamic commutation processes in situ and in vitro. Bulletin of experimental biology and medicine 2012-.......

Read More

Can summary nitrite+nitrate content serve as an indicator of NO synthesis intensity in body tissues?

Titov VY, Ivanova VY, Petrov VY, Serezhenkov VY, Mikoyan VY, Vanin VY, .Can summary nitrite+nitrate content serve as an indicator of NO synthesis intensity in body tissues? Bulletin of experimental bi.......

Read More

Content of mRNA for NMDA glutamate receptor subunits in the frontal cortex and striatum of rats after morphine withdrawal is related to the degree of abstinence.

Peregud DI, Yakovlev DI, Stepanichev DI, Onufriev DI, Panchenko DI, Gulyaeva DI, .Content of mRNA for NMDA glutamate receptor subunits in the frontal cortex and striatum of rats after morphine withdra.......

Read More