Attenuation of the vasopressor effect of angiotensin II, vasopressin and alpha 1-adrenergic stimulation by bradykinin].

Abstract Text

The role of circulating bradykinin in the regulation of cardiovascular homeostasis was studied in the normotensive conscious rat using a competitive antagonist of bradykinin at the receptor level. This antagonist (B4162) was administered intravenously as a bolus dose of 400 micrograms. This dose was shown to effectively block the hypotensive effect of exogenous bradykinin (2.5 micrograms) for at least 5 min. The bradykinin antagonist was administered at the end of an infusion of angiotensin II (1 ng/min, n = 5, or 12.5 ng/min, n = 6), of methoxamine (0.5 micrograms/min, n = 5, or 4 micrograms/min, n = 6), of lysine vasopressin (0.25 mUI/min, n = 11) or of saline (10 microliter/min, n = 7). The bradykinin antagonist did not change the mean arterial pressure of the control rats. The low doses of angiotensin II and of methoxamine did not have an effect on mean blood pressure. The bradykinin antagonist however increased mean blood pressure of these rats within 1 min by 10 +/- 2 (p less than 0.01, mean +/- SEM) and by 12 +/- 3 (p less than 0.01) mmHg, respectively. The large dose of angiotensin II raised mean blood pressure from 127 +/- 3.6 to 142 +/- 4.9 mmHg and that of methoxamine from 130 +/- 2 to 146 +/- 5 mmHg.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors :-, , , , , ,


Keywords :-, ,


Mesh Headings :-


Chemical List :-, , , , , ,



2016-09-01 16:46:39

Click download button below to get the free Attenuation of the vasopressor effect of angiotensin II, vasopressin and alpha 1-adrenergic stimulation by bradykinin]. link to pdf of abstract on your facebook profile.

Download Server - Asia Download Server - America Download Server - Europe Download Server - Australia
Citation:- Aubert JF, Waeber JF, Nussberger JF, Vavrek JF, Stewart JF, Brunner JF, .Attenuation of the vasopressor effect of angiotensin II, vasopressin and alpha 1-adrenergic stimulation by bradykinin]. Archives des maladies du coeur et des vaisseaux 1987-Jun;80()832-4 DOI:



Details of Journal

Journal Title - Archives des maladies du coeur et des vaisseaux

ISSN - 0003-9683

Volume - 80

Issue - 6

Publish date - 1987-Jun

Language - fre

Country - FRANCE


SHARE PLEASE -
Read More Similar Articles

The hypokalemic effect of adrenaline is increased by nitrendipine in normal man].

Mimran A, Ribstein A, .The hypokalemic effect of adrenaline is increased by nitrendipine in normal man]. Archives des maladies du coeur et des vaisseaux 1987-Jun;80()835-8 DOI:.......

Read More

Laurent S, Juillerat S, London S, Nussberger S, Brunner S, Safar S, .Hyperreactivity of the humeral artery to noradrenaline in essential hypertension patients]. Archives des maladies du coeur et des v.......


The role of glucocorticoids in the cardiovascular adaptation to sodium restriction in the rat].

Grünfeld JP, Eloy JP, .The role of glucocorticoids in the cardiovascular adaptation to sodium restriction in the rat]. Archives des maladies du coeur et des vaisseaux 1987-Jun;80()822-5 DOI:.......

Read More

Involvement of vasopressin in the effects of aldosterone on the arterial wall].

Angeli M, Moura M, Worcel M, .Involvement of vasopressin in the effects of aldosterone on the arterial wall]. Archives des maladies du coeur et des vaisseaux 1987-Jun;80()819-21 DOI:.......

Read More

Blood phenolsulfotransferase and monoamine oxidase-B activity in essential arterial hypertension].

Soliman H, Guicheney H, Launay H, Meyer H, Dreux H, .Blood phenolsulfotransferase and monoamine oxidase-B activity in essential arterial hypertension]. Archives des maladies du coeur et des vaisseaux .......

Read More

Measurement of platelet catecholamine content for the diagnosis of pheochromocytoma with intermittent hypertension].

Plouin PF, Chatellier PF, Billaud-Mesguich PF, Comoy PF, Duclos PF, Ménard PF, .Measurement of platelet catecholamine content for the diagnosis of pheochromocytoma with intermittent hypertension]. Ar.......

Read More

In vivo platelet activation in mild arterial hypertension].

Guicheney P, Baudouin-Legros P, Meyer P, .In vivo platelet activation in mild arterial hypertension]. Archives des maladies du coeur et des vaisseaux 1987-Jun;80()808-11 DOI:.......

Read More

Phospholipase C control of the hyperreactivity of platelets of the spontaneously hypertensive rat].

Remmal A, Koutouzov A, Girard A, Marche A, Meyer A, .Phospholipase C control of the hyperreactivity of platelets of the spontaneously hypertensive rat]. Archives des maladies du coeur et des vaisseaux.......

Read More

Changes in the inhibitory processes of platelet activation in the SHR rat].

Dard B, Baudouin-Legros B, Meyer B, .Changes in the inhibitory processes of platelet activation in the SHR rat]. Archives des maladies du coeur et des vaisseaux 1987-Jun;80()799-803 DOI:.......

Read More