Basic mechanisms of intracardiac adaptation reactions].

Abstract Text

1. When a steady plasma level of decamethonium was maintained by infusion in rats, the labelled compound became concentrated in the region of the end-plate of skeletal muscle, as shown by scintillation counting.2. The distribution of tritium-labelled decamethonium in single muscle fibres was studied by autoradiography of frozen sections, with resolution less than 1 mu.3. After intravenous injection of a dose of decamethonium which produced partial paralysis it was shown that the labelled compound had entered muscle fibres in the region of the end-plate, and for several hundred microns on either side of the end-plate.4. Entry of decamethonium could be demonstrated as early as 30 sec after intra-arterial injection. There was no evidence of any redistribution of labelled drug for a period of 2 hr after the initial entry.5. Previous administration of tubocurarine markedly reduced the entry of labelled decamethonium.

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2016-08-31 20:39:16

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Citation:- Lewartowski B, .Basic mechanisms of intracardiac adaptation reactions]. Acta physiologica Polonica 1970-;()97-112 DOI:



Details of Journal

Journal Title - Acta physiologica Polonica

ISSN - 0044-6033

Volume -

Issue - 0

Publish date - 1970-

Language - pol

Country - POLAND


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