Bioterrorism: what practicing physicians can do.

Abstract Text

Pulmonary alveolar proteinosis (PAP; the accumulation of surfactant lipids and proteins in the alveoli) has a number of infectious and environmental causes but is usually idiopathic. The clinical presentation of PAP is nonspecific; thus, the diagnosis is frequently missed, leading to inappropriate therapy and unnecessary morbidity. Recent advances suggest that a deficiency in granulocyte-macrophage colony-stimulating factor (GM-CSF) activity may lead to this surfactant accumulation. Anti-GM-CSF antibodies have been found in PAP patients, fueling speculation that PAP may be an autoimmune disease. These findings are being translated into novel forms of therapy.

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2016-09-03 12:59:09

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Citation:- Pile JC, Longworth JC, .Bioterrorism: what practicing physicians can do. Cleveland Clinic journal of medicine 2001-Dec;68()998, 1000 DOI:



Details of Journal

Journal Title - Cleveland Clinic journal of medicine

ISSN - 0891-1150

Volume - 68

Issue - 12

Publish date - 2001-Dec

Language - eng

Country - United States


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