Bone marrow transplantation generates immature oocytes and rescues long-term fertility in a preclinical mouse model of chemotherapy-induced premature ovarian failure.

Abstract Text

Although early menopause frequently occurs in female cancer patients after chemotherapy (CTx), bone marrow (BM) transplantation (BMT) has been linked to an unexplained return of ovarian function and fertility in some survivors. Studies modeling this in mice have shown that BMT generates donor-derived oocytes in CTx-treated recipients. However, a subsequent report claimed that ovulated eggs are not derived from BM and that BM-derived oocytes reported previously are misidentified immune cells. This study was conducted to further clarify the impact of BMT on female reproductive function after CTx using a preclinical mouse model.

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2016-09-04 04:59:01

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Citation:- Lee HJ, Selesniemi HJ, Niikura HJ, Niikura HJ, Klein HJ, Dombkowski HJ, .Bone marrow transplantation generates immature oocytes and rescues long-term fertility in a preclinical mouse model of chemotherapy-induced premature ovarian failure. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007-Aug;25()3198-204 DOI:



Details of Journal

Journal Title - Journal of clinical oncology : official journal of the American Society of Clinical Oncology

ISSN - 1527-7755

Volume - 25

Issue - 22

Publish date - 2007-Aug

Language - eng

Country - United States


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