Bromperidol, a new butyrophenone neuroleptic: a review.

Abstract Text

This review compares and contrasts the preclinical pharmacology of bromperidol with another butyrophenone neuroleptic, haloperidol, and the phenothiazine neuroleptic chlorpromazine. Its pharmacokinetics, biotransformation, and safety in several laboratory animal species are also summarized. These preclinical data support its use as an antipsychotic agent and show that it is well absorbed following oral administration with an apparent elimination half-life of approximately 24 h, supporting a once-daily dose regimen. Animal toxicity (including acute- and multiple-dose toxicology and reproductive and mutagenicity studies) show that bromperidol is well tolerated.

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Citation:- Dubinsky B, McGuire B, Niemegeers B, Janssen B, Weintraub B, McKenzie B, .Bromperidol, a new butyrophenone neuroleptic: a review. Psychopharmacology 1982-;78()1-7 DOI:



Details of Journal

Journal Title - Psychopharmacology

ISSN - 0033-3158

Volume - 78

Issue - 1

Publish date - 1982-

Language - eng

Country - GERMANY, WEST


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